Insulin resistance refers to insulin functions lower than that in normal condition after insulin binding with insulin receptor, manifest as increasing hepatic glucose output and decreasing the rate of glucose uptake primary into striated muscle and adipose tissue. 胰岛素抵抗是指一定量的胰岛素与其特异性受体结合后生物效应低于正常,表现为外周组织尤其是肌肉、脂肪组织对葡萄糖的摄取障碍及肝葡萄糖输出增多。